Gomzi M, Stilinovic L, Godnic-Cvar J
Med Lav. 1989 Jul-Aug;80(4):301-6.
The relationship between the serum concentration of alpha 1-antitrypsin (AAT), the concentration of dust at the workplace and lung function abnormalities was examined in 48 male workers occupationally exposed to cement dust. Measurements were performed in all subjects and included ventilatory volumes (FVC, FEV1), airway resistance (Raw), static lung volumes (RV, FRC, TLC), transfer factor for CO and AAT serum concentration. The relationship between lung function, smoking, respirable cement dust exposure, and AAT serum concentration was investigated by the method of multiple linear regression. A statistically significant correlation was observed between AAT blood concentration and respirable dust exposure. The contribution of respirable dust exposure to the description of AAT concentration was positive as was the contribution of Raw. The contributions of transfer CO, smoking and RV/TLC ratio were negative. All the variables considered accounted for approximately 30% of the total variability of the AAT concentration. To conclude, in cement workers the higher AAT serum concentration which is associated with a loss of lung function, and higher respirable cement dust concentration may be part of the defence mechanism against the potential proteolytic activity occurring in occupational dust exposure.
在48名职业性接触水泥粉尘的男性工人中，研究了血清α1 -抗胰蛋白酶（AAT）浓度、工作场所粉尘浓度与肺功能异常之间的关系。对所有受试者进行了测量，包括通气量（用力肺活量FVC、第一秒用力呼气容积FEV1）、气道阻力（Raw）、静态肺容积（残气量RV、功能残气量FRC、肺总量TLC）、一氧化碳弥散量以及AAT血清浓度。采用多元线性回归方法研究了肺功能、吸烟、可吸入水泥粉尘暴露与AAT血清浓度之间的关系。观察到AAT血浓度与可吸入粉尘暴露之间存在统计学显著相关性。可吸入粉尘暴露对AAT浓度描述的贡献为正，Raw的贡献也为正。一氧化碳弥散量、吸烟和残气量/肺总量比值的贡献为负。所有考虑的变量约占AAT浓度总变异性的30%。总之，在水泥工人中，较高的AAT血清浓度与肺功能丧失有关，较高的可吸入水泥粉尘浓度可能是针对职业粉尘暴露中潜在蛋白水解活性的防御机制的一部分。
