Perussia B, Casali P, Joppolo G, Borzini P
Boll Ist Sieroter Milan. 1976 Jul 31;55(3):235-40.
A study of lymphocytes bearing C3b, C4b and C3d complement receptor (CRL) was performed on human peripheral blood from 16 healthy donors and 12 patients affected with Chronic Lymphatic Leukemia (CLL). In the latter group a clear rise of C3dCRL was demonstrated, when compared with immunoadherence receptors bearing lymphocytes. However, when compared with controls, also these latter were slightly augmented. Furthermore in CLL under treatment CRL populations showed the same profile as CLL: so it was suggested that the treatment reduced not selectively all the three types of CRL, within the population of sIg bearing lymphocytes. Here we discuss the hypothesis that, in CLL, the proliferating lymphocytes population is chiefly sIg+, C3d+/C3b-, C4b-, but also sIg+, C3d+/C3b+, C4b+.
对16名健康供体和12名慢性淋巴细胞白血病（CLL）患者的人外周血进行了携带C3b、C4b和C3d补体受体（CRL）的淋巴细胞研究。与携带淋巴细胞的免疫黏附受体相比，后一组中C3dCRL明显升高。然而，与对照组相比，后者也略有增加。此外，在接受治疗的CLL中，CRL群体显示出与CLL相同的特征：因此有人提出，治疗并没有选择性地降低携带sIg的淋巴细胞群体中所有三种类型的CRL。在此，我们讨论这样一个假说，即在CLL中，增殖的淋巴细胞群体主要是sIg+、C3d+/C3b-、C4b-，但也有sIg+、C3d+/C3b+、C4b+。
