人类淋巴细胞带有C3b和C3d的膜受体。
Human lymphocytes bear membrane receptors for C3b and C3d.
作者信息
Eden A, Miller G W, Nussenzweig V
出版信息
J Clin Invest. 1973 Dec;52(12):3239-42. doi: 10.1172/JCI107525.
Abstract
Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.
摘要
人类外周血淋巴细胞具有针对EAC43b（用抗体和补体致敏的绵羊红细胞）以及EAC43d的膜受体，EAC43d是通过用C3b灭活剂处理EAC43b而获得的。人类粒细胞仅结合EAC43b，通过对纯化的人C3进行有限的胰蛋白酶消化获得的C3片段同时显示C3b和C3d位点，因为它们抑制淋巴细胞与EAC43b和EAC43d形成玫瑰花结。这些发现增加了一种可能性，即C3b和C3d受体位点可能选择性地分布在B淋巴细胞的正常亚群以及白血病白细胞中。
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