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植物血凝素(PHA)体外激活的T淋巴细胞上Fc和补体受体的表达。

Expression of Fc and complement receptors on T lymphocytes activated in vitro by phytohaemagglutinin (PHA).

作者信息

Smeraldi R S, Villa M G, Perussia B, Fabio G, Casali P, Rugarli C

出版信息

Immunology. 1977 Jun;32(6):827-30.

Abstract

In this work T-enriched lymphocyte populations (obtained from Ig-anti-Ig-Degalancoated columns) were studied for their surface markers, especially for Fc and complement receptors, before and after a pulse-PHA-stimulation. It has been demonstrated that activated T lymphocytes express on their surface both of these markers in high percentage. The hypothesis is discussed that B and T lymphocytes differ only with regard to the presence of surface immunoglobulins or the ability of forming spontaneous rosettes. On the contrary the other surface markers may probably be expressed when needed functionally by the cells.

摘要

在这项研究中,对富含T细胞的淋巴细胞群体(从Ig - 抗Ig - 德加朗科包被柱获得)在脉冲PHA刺激前后进行了表面标志物研究,特别是Fc和补体受体。已证明活化的T淋巴细胞在其表面高比例表达这两种标志物。讨论了关于B淋巴细胞和T淋巴细胞仅在表面免疫球蛋白的存在或形成自发玫瑰花结的能力方面存在差异的假说。相反,其他表面标志物可能在细胞功能需要时表达。

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Membrane antigenic changes associated with PHA transformation of mouse spleen cells in vitro.
Immunol Commun. 1974;3(4):337-49. doi: 10.3109/08820137409061114.

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