Ugazio A G, Altamura D, Giraudi V, Mingrat G, Belloni C, Burgio G R
Boll Ist Sieroter Milan. 1976;55(5):451-9.
Monocyte-depleted lymphocyte suspensions from the peripheral blood of 36 healthy newborns and 23 adults were compared as to percent of cells forming rosettes with sheep erythrocytes (T lymphocytes) and proliferative responses after in vitro culture with various doses of Phytohemagglutinin, Concanavalin A and Pokeweed mitogen. No significant difference was found between the proportions of T lymphocytes of newborns and adults. Mitogen responsiveness of the newborn lymphocytes showed dramatic between-subject variability completely unrelated to the proportion of T lymphocytes. It is suggested that during neonatal life there is massive variable recirculation of T lymphocytes subsets (and/or stages of maturation) characterized by differential degrees of responsiveness to the mitogens tested.
对36名健康新生儿和23名成年人外周血中去除单核细胞的淋巴细胞悬液进行了比较，比较内容包括与绵羊红细胞形成玫瑰花结的细胞百分比（T淋巴细胞），以及在体外与不同剂量的植物血凝素、刀豆蛋白A和商陆有丝分裂原培养后的增殖反应。新生儿和成年人的T淋巴细胞比例之间未发现显著差异。新生儿淋巴细胞的有丝分裂原反应性在个体间表现出巨大差异，且与T淋巴细胞的比例完全无关。这表明在新生儿期，T淋巴细胞亚群（和/或成熟阶段）存在大量可变的再循环，其特征是对所测试的有丝分裂原具有不同程度的反应性。
