Victorino R M, Hodgson H J
Clin Exp Immunol. 1980 Dec;42(3):571-8.
A simultaneous analysis was made of numbers and proportions of T cell subsets (T mu and T gamma cells), lymphocyte responsiveness to non-specific mitogens in vitro and 'short-lived suppressor cell activity' in peripheral blood mononuclear cells (PBMC) of normal individuals. No correlation was found between either T gamma or T mu cells and the 'short-lived suppressor cell activity', suggesting that suppression in this system is not a reflection of quantitative alteration in these subsets. However, a highly significant positive correlation was found between numbers of T mu cells and PBMC responses to the mitogens phytohaemagglutinin, concanavalin A and pokeweek mitogen. This may reflect either a helper effect of T mu cells on lymphocyte proliferation in response to mitogens or the presence of the majority of mitogen-responsive cells within this subpopulation. As in normal individuals lymphocyte responsiveness correlates with the number of circulating T mu cells, it is possible that a reduction in these cells in disease states may contribute to defects in cell-mediated immunity.
对正常个体外周血单个核细胞（PBMC）中的T细胞亚群（Tμ和Tγ细胞）数量及比例、淋巴细胞对非特异性有丝分裂原的体外反应性以及“短期抑制细胞活性”进行了同步分析。未发现Tγ或Tμ细胞与“短期抑制细胞活性”之间存在相关性，这表明该系统中的抑制作用并非这些亚群数量改变的反映。然而，发现Tμ细胞数量与PBMC对植物血凝素、刀豆球蛋白A和商陆有丝分裂原等有丝分裂原的反应之间存在高度显著的正相关。这可能反映了Tμ细胞对淋巴细胞对有丝分裂原反应的增殖具有辅助作用，或者该亚群中存在大多数对有丝分裂原反应的细胞。由于在正常个体中淋巴细胞反应性与循环Tμ细胞数量相关，因此在疾病状态下这些细胞数量的减少可能导致细胞介导免疫缺陷。
