Lopez J B, Balasegaram M, Thambyrajah V, Timor J
Division of Endocrinology, Institute for Medical Research, Kuala Lumpur, Malaysia.
Malays J Pathol. 1996 Dec;18(2):95-9.
This study was undertaken to see if liver function tests (LFT) served a worthwhile purpose in the investigation of hepatocellular carcinoma (HCC). Sera from 80 HCC, 76 benign liver disease (BLD) and 152 healthy adult (HA) subjects were assayed for alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), alanine aminotransferase and lactate dehydrogenase, bilirubin and albumin. Cut-off values were determined from the HA. ALP, GGT, AST and albumin were abnormal in about 90% of the HCC. With the exception of bilirubin, the LFT were abnormal more frequently in HCC than in chronic hepatitis and cirrhosis, the conditions which preceed it. Raised ALP in the presence of normal bilirubin was more often a feature of HCC than BLD although this relationship was not statistically significant. It seems unlikely that LFT serve a useful function in HCC.
本研究旨在探讨肝功能检查（LFT）在肝细胞癌（HCC）的调查中是否具有重要意义。对80例HCC患者、76例良性肝病（BLD）患者和152例健康成年人（HA）的血清进行了碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶和乳酸脱氢酶、胆红素及白蛋白的检测。根据HA人群确定临界值。约90%的HCC患者ALP、GGT、AST和白蛋白异常。除胆红素外，HCC患者的LFT异常比其前驱疾病慢性肝炎和肝硬化更为常见。在胆红素正常的情况下，HCC患者ALP升高比BLD患者更为常见，尽管这种关系无统计学意义。LFT似乎对HCC并无有用作用。
