Kovacs F M, García A, Mufraggi N, García F, Pavía J, Prandi D, Gotzens V, Giralt I, Piera C, Setoain J
Kovacs Foundation, Palma de Mallorca, Spain.
Eur Radiol. 2000;10(6):1019-25. doi: 10.1007/s003300051056.
Hypodermic injection of technetium-99m (99mTc-pertechnetate) at points of low electrical resistance give rise to rapid, longitudinal, and progressive diffusion of the radioactive tracer. We assessed the effect of cutaneous incisions that did not intersect the migration trajectory of 99mTc-pertechnetate and the re-establishment of pathways after the suture of incisions that intersected the migration trajectory. Linear and rapid migration of 99mTc-pertechnetate was not altered or prevented by incisions that did not intersect the migration pathway. Different patterns of 99mTc-pertechnetate spread were found when incisions intersected the radioactive pathways until restoration of the normal migration pathway observed in undamaged skin occurred. In all experiments in which migration of 99mTc-pertechnetate was observed, lavage of surgical wounds was followed by disappearance of the 99mTc-pertechnetate migration observed around the suture. Linear migration of the tracer was not observed when the incision was left uncovered, filled with petroleum jelly, or with a solid silicone sheet, but it was seen when non-sutured incisions were filled with transonic or silicone gel or covered with a solid silicone sheet parallel to the cutaneous plane. These data show that after a cutaneous incision that intersected the diffusion trajectory of the radioactive tracer, linear migration of 99mTc-pertechnetate hypodermically injected at points of low electrical resistance was restored before healing of the cutaneous incision and was independent of incisions made on the skin not overlying the radioactive pathway. A mechanism similar to that of capillary electrophoresis is suggested to explain the hypodermic diffusion of inert particles through specific and constant linear pathways.
在低电阻点皮下注射锝-99m（高锝酸盐）会使放射性示踪剂快速、纵向且进行性扩散。我们评估了未与高锝酸盐迁移轨迹相交的皮肤切口的影响，以及与迁移轨迹相交的切口缝合后通路的重新建立情况。未与迁移通路相交的切口不会改变或阻止高锝酸盐的线性快速迁移。当切口与放射性通路相交时，会发现高锝酸盐的不同扩散模式，直到在未受损皮肤中观察到的正常迁移通路恢复。在所有观察到高锝酸盐迁移的实验中，对手术伤口进行冲洗后，缝合处周围观察到的高锝酸盐迁移消失。当切口不覆盖、填充凡士林或固体硅树脂片时，未观察到示踪剂的线性迁移，但当未缝合的切口填充超声凝胶或硅凝胶或覆盖与皮肤平面平行的固体硅树脂片时，可以观察到线性迁移。这些数据表明，在与放射性示踪剂扩散轨迹相交的皮肤切口后，在皮肤切口愈合之前，在低电阻点皮下注射的高锝酸盐的线性迁移得以恢复，并且与未覆盖放射性通路的皮肤上所做的切口无关。有人提出一种类似于毛细管电泳的机制来解释惰性颗粒通过特定且恒定的线性通路进行皮下扩散。
