Kovacs F M, Gotzens V, García A, García F, Mufraggi N, Prandi D, Setoain J, San Román F
Kovacs Foundation, Palma de Mallorca, Spain.
Eur J Nucl Med. 1993 Jul;20(7):585-90. doi: 10.1007/BF00176552.
We investigated the involvement of cutaneous structures in specific linear migration pathways of technetium-99m pertechnetate hypodermically injected at points of low electrical resistance in the metacarpus of male beagles. Skin-deep incisions were made in the front or back legs on either the same side as the 99mTc injection or on the opposite side. Incisions in the back legs did not affect the migration pattern. Incisions in the front legs before the injection of 99mTc prevented tracer migration. After the injection of 99mTc, incisions in the front contralateral leg caused sudden cessation of the migration, while incisions in the ipsilateral leg caused immediate disappearance of the pathway previously observed. Radioactivity was not detected in flaps obtained from the skin overlying the migration pathway or from the corresponding area of the contralateral leg. In conclusion, the specific linear migration pathways of 99mTc hypodermically injected at points of low electrical resistance cannot be explained by any known biological function. Although the migration of 99mTc does not seem to be strongly linked to any cutaneous structure, the skin overlying the radioactive pathway and the corresponding area of the contralateral leg must be intact if tracer migration is to take place.
我们研究了在雄性比格犬掌骨低电阻点皮下注射高锝[99mTc]酸盐时，皮肤结构在其特定线性迁移途径中的作用。在与99mTc注射同侧或对侧的前腿或后腿上做皮肤浅层切口。后腿的切口不影响迁移模式。在注射99mTc之前在前腿做切口会阻止示踪剂迁移。注射99mTc后，对侧前腿的切口会导致迁移突然停止，而同侧腿的切口会使先前观察到的迁移途径立即消失。在迁移途径上方皮肤或对侧腿相应区域获取的皮瓣中未检测到放射性。总之，在低电阻点皮下注射的99mTc的特定线性迁移途径无法用任何已知生物学功能来解释。尽管99mTc的迁移似乎与任何皮肤结构没有紧密联系，但如果示踪剂要发生迁移，放射性途径上方的皮肤和对侧腿的相应区域必须完整。
