慢性阻塞性肺疾病患者红细胞中的碳酸酐酶同工酶B

Carbonic anhydrase isoenzyme B in erythrocytes of subjects with chronic obstructive lung disease.

作者信息

Anker N, Mondrup M

出版信息

Scand J Respir Dis. 1979 Feb;60(1):1-5.

Abstract

A specific and quantitative immunological method for the determination of human erythrocyte carbonic anhydrase (HCA) isoenzyme B has been used to determine the contents of enzyme in the erythrocytes from healthy persons and from subjects with chronic obstructive lung disease. The investigations have shown a statistically significant increase of HCA type B in the erythrocytes of subjects suffering from chronic obstructive lung disease and hypercapnia. Subjects with chronic obstructive lung disease and normal PaCO2 showed no difference from normal subjects. No correlation was found between PaCO2 and human erythrocyte carbonic anhydrase.

摘要

一种用于测定人红细胞碳酸酐酶（HCA）同工酶B的特异性定量免疫方法，已被用于测定健康人和慢性阻塞性肺疾病患者红细胞中的酶含量。研究表明，患有慢性阻塞性肺疾病和高碳酸血症的患者红细胞中B型HCA有统计学意义的增加。患有慢性阻塞性肺疾病且动脉血二氧化碳分压（PaCO2）正常的患者与正常受试者无差异。未发现PaCO2与人体红细胞碳酸酐酶之间存在相关性。