Kondo T, Taniguchi N, Kawakami Y, ide H, Saito K
Tohoku J Exp Med. 1975 Dec;117(4):351-6. doi: 10.1620/tjem.117.351.
The levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease. A significant increase in the level of carbonic anhydrase B was observed in these patients, while the level of carbonic anhydrase C did not change substantially. Positive correlations were found between the level of carbonic anhydrase B and arterial CO2 tension and plasma HCO3 concentration. A negative correlation was observed between the levels of carbonic anhydrase B and blood pH. These findings suggest that the synthesis or degradation of carbonic anhydrase B isozyme is affected by arterial CO2 tension or plasma HC03 concentration. The clinical significance was also discussed in relation to these isozyme levels in red cell.
采用定量免疫技术测定了慢性阻塞性肺疾病患者红细胞中碳酸酐酶B和C同工酶的水平。这些患者中观察到碳酸酐酶B水平显著升高，而碳酸酐酶C水平基本未变。碳酸酐酶B水平与动脉血二氧化碳分压及血浆碳酸氢根浓度呈正相关。碳酸酐酶B水平与血液pH呈负相关。这些发现提示碳酸酐酶B同工酶的合成或降解受动脉血二氧化碳分压或血浆碳酸氢根浓度影响。还讨论了这些红细胞同工酶水平的临床意义。
