Gerard R, Burlot J, Levy S, Balansard P, Jullien G, Ebagosti A
Acta Cardiol. 1976;31(5):385-99.
Electrophysiologic studies were carried out on 10 patients before and during therapy by Fenoxedil Chlorhydrate a new anti-arrhythmic drug, to determine the effects on cardiac conduction. Fenoxedil Chlorhydrate produces a constant alteration of intra-nodal conduction. Modification of sinus function are less evident. Auricular and ventricular refractory periods are increased in the majority of cases. These results give a better understanding of mecanism of this drug, and helps in its prescription in clinical practice.
对10例患者在使用新型抗心律失常药物盐酸苯氧苄胺治疗前和治疗期间进行了电生理研究,以确定其对心脏传导的影响。盐酸苯氧苄胺可使结内传导持续改变。对窦房结功能的影响不太明显。大多数情况下,心房和心室的不应期会延长。这些结果有助于更好地理解该药物的作用机制,并有助于其在临床实践中的处方应用。