Allal J, Bonneau A, Poupet J Y, Barraine R, Rousseau G
Arch Mal Coeur Vaiss. 1984 Jan;77(1):85-91.
One hundred and twelve patients with atrial fibrillation of different causes were treated with fenoxedil chlorhydrate. Sinus rhythm was restored in 81 cases (72.3 p. 100). The best results were obtained in the following conditions: hypertensive heart disease (77.6 p. 100), ischemic heart disease (75 p. 100), idiopathic atrial fibrillation (76.4 p. 100), senile lone fibrillation (78.2 p. 100). The results were average in valvular heart disease (57.1 p. 100) and in hyperthyroidism (40%). Age did not appear to be a deciding factor, the overall results being comparable in patients under 70 years of age (70.8 p. 100) and over 70 years of age (73.4 p. 100). Although recent atrial fibrillation was reduced more easily (83.3 p. 100), the results were satisfactory in chronic arrhythmias (over 3 years) (77.7 p. 100). The success rate was 76.3 p. 100 when the cardiothoracic index was over 0.60, and 66.6 p. 100 when less than 0.60. The antiarrhythmic effect of fenoxedil chlorhydrate is related to its electrophysiological properties as it depresses sinus node activity and atrioventricular conduction. No arrhythmic or conduction complications were observed during a short period (maximum 5 days) of close monitoring. However, lengthening of the QT and PR intervals was a common phenomenon. The advantages of fenoxedil chlorhydrate over electrical cardioversion (atraumatic, possibility of associating digitalis) and the results obtained whilst respecting the prescribing advice, justify its adoption as a method of converting atrial fibrillation.
112例不同病因的心房颤动患者接受了盐酸苯氧苄胺治疗。81例（72.3%）恢复了窦性心律。在以下情况中取得了最佳效果：高血压性心脏病（77.6%）、缺血性心脏病（75%）、特发性心房颤动（76.4%）、老年孤立性心房颤动（78.2%）。瓣膜性心脏病（57.1%）和甲状腺功能亢进症（40%）的效果一般。年龄似乎不是一个决定性因素，70岁以下患者（70.8%）和70岁以上患者（73.4%）的总体结果相当。虽然近期心房颤动更容易得到纠正（83.3%），但慢性心律失常（超过3年）的效果也令人满意（77.7%）。心胸指数超过0.60时成功率为76.3%，低于0.60时为66.6%。盐酸苯氧苄胺的抗心律失常作用与其电生理特性有关，因为它会抑制窦房结活动和房室传导。在短期（最长5天）密切监测期间未观察到心律失常或传导并发症。然而，QT和PR间期延长是常见现象。盐酸苯氧苄胺相对于电复律的优势（无创、可联合使用洋地黄）以及在遵循处方建议时获得的结果，证明将其作为转复心房颤动的一种方法是合理的。
