Gmeiner R, Ng C K, Simma H, Gstöttner M
Eur J Cardiol. 1979 Jan;9(1):77-86.
Using His bundle electrograms and atrial pacing the effects of Ro 11-1781, a new calcium antagonist, was studied in 13 patients with normal A--V conduction. Following an intravenous bolus of 2 mg/kg Ro 11-1781 the A--V nodal conduction time (A--H interval) was prolonged in all patients during sinus rhythm, atrial incremental and premature pacing. Wenckebach periods above the bundle of His occurred at lower atrial driving rates following the drug. The functional and effective refractory period of the A--V node were prolonged after the administration of Ro 11-1781. No significant effect of Ro 11-1781 on the remainder of the conduction system was observed. Heart rate and the corrected sinus node recovery time changed variably. The increase of the A--H time in response to Ro 11-1781 was completely reversed by Atropine.
利用希氏束电图和心房起搏，对13例房室传导正常的患者研究了一种新型钙拮抗剂Ro 11 - 1781的作用。静脉推注2mg/kg Ro 11 - 1781后，在窦性心律、心房递增起搏和早搏起搏期间，所有患者的房室结传导时间（A - H间期）均延长。用药后，希氏束以上的文氏周期在较低的心房驱动频率时出现。给予Ro 11 - 1781后，房室结的功能和有效不应期延长。未观察到Ro 11 - 1781对传导系统其余部分有显著影响。心率和校正的窦房结恢复时间变化不定。阿托品可完全逆转Ro 11 - 1781引起的A - H时间增加。
