Cochener B, Kling F, Savary-Le Floch G, Colin J
Service d'Ophtalmologie, CHU Morvan, 5, avenue-Foch, 29609 Brest Cedex.
J Fr Ophtalmol. 2000 Jun;23(6):555-62.
To compare effect of two topical non steroidal anti-inflammatory (NSAI) drugs: Indomethacin (Indocollyre)0.1 %, Chauvin Inc.) and Diclofenac (Voltaren 0.1%, Cibavision) on postoperative pain and epithelial regrowth following surface excimer photoablation.
Eighty-six excimer operated patients, were divided in two similar groups depending on the NSAI instilled postoperatively and for 3 days (4 drops daily). No patient was informed of any other available drug. Pain intensity was quantified between 1 and 10 according to an analog scale (reported from 1 to 10 hours, then 4 times a day during 7 days). Complementary medications and functional symptoms were also notified. Biomicroscopic evaluation using fluorescein test was performed to assess reepithelialization.
In term of pain, no significative difference was observed between the two groups concerning intensity, associated medications, or numbers of days of discomfort. Controversially, retreated eyes might induce more pain than initial treatments. No delay in epithelial regrowth was noted and the difference between the two groups in functional complaints was no statistically significant. Pain appears to be not related to ablation depth. DISCUSSION- CONCLUSION: Our results are correlated to literature reported data. Introduction of NSAI constitutes a real advent in the care of excimer postoperative pain. Effect of indomethacin seems comparable to diclofenac effect, but might be of interest because of no anesthetic property that might guarantee of no delay in wound healing response.
比较两种局部用非甾体抗炎药（NSAI）：0.1%吲哚美辛（吲哚美辛滴眼液，乔文公司）和0.1%双氯芬酸（扶他林滴眼液，西巴视力公司）对表面准分子激光光凝术后疼痛和上皮再生的影响。
86例接受准分子激光手术的患者，根据术后滴注的NSAI药物分为两组，术后3天每天滴注4次。没有患者被告知任何其他可用药物。根据模拟量表将疼痛强度量化为1至10级（术后1至10小时报告，然后在7天内每天报告4次）。还记录了辅助用药和功能症状。使用荧光素试验进行生物显微镜评估以评估上皮再形成。
在疼痛方面，两组在强度、相关用药或不适天数方面未观察到显著差异。有争议的是，再次治疗的眼睛可能比初次治疗引起更多疼痛。未观察到上皮再生延迟，两组在功能主诉方面的差异无统计学意义。疼痛似乎与消融深度无关。讨论 - 结论：我们的结果与文献报道的数据相关。NSAI的引入是准分子激光术后疼痛护理方面的一项真正进展。吲哚美辛的效果似乎与双氯芬酸的效果相当，但可能因其无麻醉特性而具有优势，这可能保证伤口愈合反应不会延迟。
