Pecher P, Schumacher B A
Department of Cardiac Surgery, University Hospital Ulm, Germany.
Ann Thorac Surg. 2000 May;69(5):1414-9. doi: 10.1016/s0003-4975(00)01162-0.
Using the human fibroblast growth factor we could already demonstrate the induction of neoangiogenesis in the ischemic human myocardium.
Forty patients, who were undergoing elective coronary artery bypass grafting were randomly selected and allotted either to a treatment or a control group. In 20 patients (study group) fibroblast growth factor was injected directly into the myocardium, close to the left anterior descending coronary artery. The control group comprised 20 patients who had been injected with heat denatured fibroblast growth factor. The 3-year follow-up consisted of a clinical examination, echocardiography, and selective imaging of the internal mammary artery bypass using angiography.
As with the early results, a dense new capillary network could be demonstrated angiographically in the region where the factor had been injected. Echocardiography showed an increase in the left ventricular ejection fraction in the study group. We also found a more pronounced improvement in the clinical appearance of the patients with fibroblast growth factor.
Fibroblast growth factor, in addition to operative myocardial revascularization, may be the appropriate treatment for patients with peripheral stenosis or diffuse coronary arteriosclerosis. It is necessary to confirm these results in further studies on a larger group of patients.
利用人类成纤维细胞生长因子，我们已能证明其可诱导缺血性人类心肌中的新生血管形成。
随机选取40例行择期冠状动脉旁路移植术的患者，并将其分为治疗组或对照组。20例患者（研究组）在靠近左前降支冠状动脉处将成纤维细胞生长因子直接注入心肌。对照组由20例注射了热变性成纤维细胞生长因子的患者组成。3年随访包括临床检查、超声心动图以及使用血管造影术对乳内动脉旁路进行选择性成像。
与早期结果一样，血管造影显示在注入因子的区域有密集的新毛细血管网络。超声心动图显示研究组左心室射血分数增加。我们还发现接受成纤维细胞生长因子治疗的患者临床症状改善更为明显。
除了手术性心肌血运重建外，成纤维细胞生长因子可能是治疗外周狭窄或弥漫性冠状动脉粥样硬化患者的合适疗法。有必要在更多患者的进一步研究中证实这些结果。
