Kipps T J
Department of Medicine, University of California, San Diego, La Jolla 92093-0663, USA.
Curr Opin Hematol. 2000 Jul;7(4):223-34. doi: 10.1097/00062752-200007000-00005.
Chronic lymphocytic leukemia continues to attract much basic and clinical research interest. Despite recent advances, the disease still has no established cure. Nonetheless, significant strides have been made in our understanding of the genetics, biology, and clinical staging of this disease. This understanding may improve our ability to segregate patients into subtypes that differ in their cytogenesis, propensity toward disease progression, or response to standard or innovative forms of therapy. Finally, several promising new modalities of treatment are being evaluated in clinical trials, involving novel drugs or drug-combinations, monoclonal antibodies, stem cell transplantation, or gene therapy.
慢性淋巴细胞白血病继续吸引着众多基础和临床研究的关注。尽管最近取得了进展，但该疾病仍无既定的治愈方法。然而，我们对这种疾病的遗传学、生物学和临床分期的理解已经取得了重大进展。这种理解可能会提高我们将患者分为细胞发生、疾病进展倾向或对标准或创新治疗形式的反应不同的亚型的能力。最后，几种有前景的新治疗方式正在临床试验中进行评估，包括新型药物或药物组合、单克隆抗体、干细胞移植或基因治疗。
