Ijiri R, Tanaka Y, Hara M, Sekido K
Department of Pathology, Kanagawa Children Medical Center, Japan.
Childs Nerv Syst. 2000 May;16(5):304-8. doi: 10.1007/s003810050519.
Radiation-associated meningioma in a child is rare. We report a case of xanthomatous meningioma, a rare subtype even in the adult population, which occurred in a 10-year-old boy who had undergone irradiation therapy for ependymoma at the age of 2 years. Histological examination of the tumor revealed a mixture of meningothelial cells and abundant foamy xanthomatous cells, with no apparent atypical cellular features. Xanthomatous meningioma associated with therapeutic high-dose irradiation in a child has not yet been documented. Immunohistochemical studies and the clinical course are evaluated with a review of the literature.
儿童辐射相关的脑膜瘤很罕见。我们报告一例黄色瘤型脑膜瘤,即使在成人中也是罕见亚型,发生于一名10岁男孩,该男孩在2岁时因室管膜瘤接受过放射治疗。肿瘤的组织学检查显示脑膜内皮细胞和大量泡沫状黄色瘤细胞混合存在,无明显的非典型细胞特征。儿童中与治疗性高剂量辐射相关的黄色瘤型脑膜瘤尚未见文献记载。通过文献复习对免疫组织化学研究和临床病程进行评估。