[婴儿期接受视网膜母细胞瘤放射治疗疗程的患者中基底骨翼部脑膜瘤（3例分析）]

[Meningiomas of the wings of the basilar bone in patients undergone a course of radiation therapy for retinoblastoma in infancy (analysis of 3 cases)].

作者信息

Kadasheva A B, Cherekaev V A, Kozlov A V, Belov A I, Zaĭtsev A M, Kudriavtseva P A

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 2004 Jul-Sep(3):24-7; discussion 27.

DOI:

Abstract

The paper presents 3 cases of radio-induced meningiomas in patients who underwent irradiation for retinoblastoma in infancy. Meningiomas of the middle cranial fossa were diagnosed in women aged 16, 34, and 47 years. Radiation therapy was in the complex treatment of retinoblastoma in all patients in infancy (4 months to 3 years). The latent period between the irradiation and diagnosis of meningioma was 15 to 44 years. The location of detected meningiomas (the wings of the basilar bone on the side of exenteration or enucleation) corresponded to the irradiation fields. Surgical treatment yielded good results. Histological study has indicated that meningiomas were fibroblastic in the former two cases and atypical meningioma was verified in the third case when the tumor infitratively spread. Our observations support the fact that there may be radio-induced meningiomas in the area exposed to irradiation.

摘要

本文报告了3例婴儿期因视网膜母细胞瘤接受放疗后发生放射性脑膜瘤的病例。3例中颅窝脑膜瘤患者年龄分别为16岁、34岁和47岁，均为女性。所有患者在婴儿期（4个月至3岁）接受了视网膜母细胞瘤综合治疗中的放射治疗。放疗与脑膜瘤诊断之间的潜伏期为15至44年。所发现脑膜瘤的位置（眼球摘除或眼球剜出侧的颅底骨翼）与放疗野相对应。手术治疗效果良好。组织学研究表明，前两例脑膜瘤为纤维母细胞型，第三例肿瘤呈浸润性生长，经证实为非典型脑膜瘤。我们的观察结果支持以下事实：在接受放疗的区域可能会发生放射性脑膜瘤。