Esterre P, Plichart C, Huin-Blondey M O, Nguyen L
Immunology Unit, Institut Territorial de Recherches Médicales Louis Malardé, Tahiti, French Polynesia.
Parasite. 2000 Jun;7(2):91-4. doi: 10.1051/parasite/2000072091.
Growing evidence suggest that secondary bacterial, mainly streptococcal, infections contribute significantly to recurrent episodes of acute adenolymphangitis (ADL) of filarial origin. We examined the role of group A streptococci in the progression of lymphedema in Polynesian patients with filariasis-related ADL (22 cases) or chronic pathology (10 cases), or with erysipela (10 patients) and, as controls, in 20 healthy adults. Antistreptolysin O (ASLO) and anti-streptodornase B (ASDB) titers were systematically determined in parallel to parasitological and biochemical tests. ASLO and ASDB assays were positive in 100% of erysipela, 75% of filarial ADL as compared to 50% of chronic pathology and 39% of healthy controls. Interestingly, by opposition to ASLO titers which were not significantly different between the four groups, ASDB titers were higher in ADL (p = 0.019) and erysipela (p = 0.002) than in controls. These results support the hypothesis that recurrent streptococcal infections may have an important role in the pathogenesis of ADL in lymphatic filariasis.
越来越多的证据表明，继发性细菌感染，主要是链球菌感染，在丝虫源性急性腺淋巴管炎（ADL）的复发中起重要作用。我们研究了A组链球菌在患有丝虫病相关ADL（22例）或慢性病变（10例）的波利尼西亚患者或丹毒患者（10例）的淋巴水肿进展中的作用，并以20名健康成年人作为对照。在进行寄生虫学和生化检测的同时，系统地测定抗链球菌溶血素O（ASLO）和抗链道酶B（ASDB）滴度。丹毒患者中ASLO和ASDB检测均为阳性，丝虫性ADL患者中阳性率为75%，而慢性病变患者中为50%，健康对照者中为39%。有趣的是，与四组之间无显著差异的ASLO滴度相反，ADL患者（p = 0.019）和丹毒患者（p = 0.002）的ASDB滴度高于对照组。这些结果支持了复发性链球菌感染可能在淋巴丝虫病ADL发病机制中起重要作用的假说。
