Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning.
作者信息
Steinborn R, Schinogl P, Zakhartchenko V, Achmann R, Schernthaner W, Stojkovic M, Wolf E, Müller M, Brem G
机构信息
[1] Institute of Animal Breeding Genetics, University of Veterinary Medicine, Vienna, Austria.
出版信息
Nat Genet. 2000 Jul;25(3):255-7. doi: 10.1038/77000.
DOI:10.1038/77000
PMID:10888867
Abstract
Mammals have been cloned from adult donor cells. Here we report the first cases of mitochondrial DNA (mtDNA) heteroplasmy in adult mammalian clones generated from fetal and adult donor cells. The heteroplasmic clones included a healthy cattle equivalent of the sheep Dolly, for which a lack of heteroplasmy was reported.
摘要
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