McFeely W J, Bojrab D I, Kartush J M
Michigan Ear Institute and Providence Hospital, USA.
Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):17-21. doi: 10.1067/mhn.2000.105920.
Some patients lack quality autologous tissue for tympanic membrane (TM) grafting. AlloDerm (LifeCell Corp, The Woodlands, TX) is a preserved allograft that has been effective in nonotologic applications.
The goal of this study was to investigate AlloDerm in the repair of chronic TM perforations.
Ten adult chinchillas underwent a controlled, 2-stage procedure for creation and repair of bilateral TM perforations. Myringoplasties were performed. The control side (left) was repaired with autologous fascia; AlloDerm was used in all right ears. Grafts were assessed at 3 to 8 weeks.
Complete TM perforation closure was noted in 9 of 10 (90%) control ears and 8 of 10 (80%) AlloDerm-treated ears. Fascia and AlloDerm integrated consistently with host tissues. No variables demonstrated statistical significance.
AlloDerm appeared to be an ideal substitute for grafting of the TM. It was equally effective as fascia. Clinical trials in human beings appear warranted. Potential health care savings are discussed.
一些患者缺乏用于鼓膜（TM）移植的优质自体组织。AlloDerm（LifeCell公司，得克萨斯州伍德兰兹）是一种经过保存的同种异体移植物，已在非耳科应用中显示出有效性。
本研究的目的是探讨AlloDerm在慢性TM穿孔修复中的应用。
10只成年龙猫接受了一项对照的两阶段手术，用于双侧TM穿孔的创建和修复。进行了鼓膜成形术。对照侧（左侧）用自体筋膜修复；所有右侧耳朵使用AlloDerm。在3至8周时对移植物进行评估。
10只对照耳中有9只（90%）和10只接受AlloDerm治疗的耳朵中有8只（80%）观察到TM穿孔完全闭合。筋膜和AlloDerm与宿主组织始终保持整合。没有变量显示出统计学意义。
AlloDerm似乎是TM移植的理想替代品。它与筋膜同样有效。似乎有必要在人类中进行临床试验。讨论了潜在的医疗保健节省。
