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使用同种异体脱细胞真皮基质治疗慢性中耳炎的初步结果。

Preliminary results with the use of AlloDerm in chronic otitis media.

作者信息

Fayad Jose N, Baino Tony, Parisier Simon C

机构信息

Department of Otolaryngology-Head & Neck Surgery, Columbia University College of Physicians and Surgeons, The New York-Presbyterian Hospital, 180 Fort Washington Avenue, Harkness Pavilion, Suite 813, New York, NY 10032, USA.

出版信息

Laryngoscope. 2003 Jul;113(7):1228-30. doi: 10.1097/00005537-200307000-00022.

Abstract

OBJECTIVES/HYPOTHESIS: AlloDerm, an acellular dermal graft, has been used successfully as a material for soft tissue implantation. The authors report their experience with the use of AlloDerm in the reconstruction of the tympanic membrane.

STUDY DESIGN

Case review study.

METHODS

Charts were reviewed for all patients who underwent tympanoplasty with and without mastoidectomy between June 1999 and June 2002 in whom AlloDerm was used as a grafting material. There were 24 patients, 17 with simple perforations (8 revisions) and 7 with chronic otitis media with cholesteatoma (6 revisions). Success was defined as closure of the tympanic membrane perforation.

RESULTS

Closure of the perforation using AlloDerm was achieved in 87.5% of the patients (ie, in all but three patients). Another patient developed serous otitis media and required a myringotomy tube in the postoperative period.

CONCLUSIONS

The success rate for AlloDerm in tympanoplasty was similar to that of temporalis fascia in the authors' experience. AlloDerm can provide a suitable grafting material when fascia is not available or when the size of the defect precludes the use of fascia.

摘要

目的/假设:脱细胞真皮基质(AlloDerm)是一种无细胞真皮移植物,已成功用作软组织植入材料。作者报告了他们使用AlloDerm重建鼓膜的经验。

研究设计

病例回顾性研究。

方法

回顾了1999年6月至2002年6月期间所有接受鼓室成形术(伴或不伴乳突切除术)且使用AlloDerm作为移植材料的患者的病历。共有24例患者,其中17例为单纯鼓膜穿孔(8例翻修),7例为慢性胆脂瘤型中耳炎(6例翻修)。成功定义为鼓膜穿孔闭合。

结果

87.5%的患者(即除3例患者外的所有患者)使用AlloDerm实现了穿孔闭合。另1例患者发生浆液性中耳炎,术后需要放置鼓膜切开置管。

结论

根据作者的经验,AlloDerm在鼓室成形术中的成功率与颞肌筋膜相似。当无法获得筋膜或缺损大小不适合使用筋膜时,AlloDerm可提供合适的移植材料。

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