Stewart M G, Donovan D T, Parke R B, Bautista M H
Bobby R. Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030, USA.
Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):81-4. doi: 10.1067/mhn.2000.105922.
We studied the association between the severity of pretreatment CT scan findings and the improvement in symptoms of chronic sinusitis after treatment.
We analyzed data from an ongoing prospective, nonrandomized clinical outcomes study of patients treated for chronic sinusitis at a tertiary-care academic medical center (n = 57, mean age 46.8 years). Disease-specific symptom severity was measured with a validated health status instrument, and CT stage was quantified with the Harvard CT staging system.
In a multivariate analysis, symptom severity based on CT findings emerged as a strong predictor of both improvement in symptom score outcome (beta = 0.47, P = 0.01) and absolute symptom level after treatment (beta = -0.58, P = 0.001).
Severity as assessed by a pretreatment CT scan is a strong predictor of outcome. Patients with higher symptom severity based on CT scans showed significantly larger improvement and lower absolute levels of symptom severity after treatment. This study links CT scan findings and subjective patient-based outcomes (symptom scores) using a validated outcomes instrument.
我们研究了治疗前CT扫描结果的严重程度与慢性鼻窦炎治疗后症状改善之间的关联。
我们分析了来自一家三级医疗学术医学中心正在进行的慢性鼻窦炎患者前瞻性、非随机临床结局研究的数据（n = 57，平均年龄46.8岁）。使用经过验证的健康状况工具测量特定疾病的症状严重程度，并用哈佛CT分期系统对CT分期进行量化。
在多变量分析中，基于CT结果的症状严重程度成为症状评分结局改善（β = 0.47，P = 0.01）和治疗后绝对症状水平（β = -0.58，P = 0.001）的有力预测指标。
治疗前CT扫描评估的严重程度是结局的有力预测指标。基于CT扫描症状严重程度较高的患者在治疗后显示出明显更大的改善和更低的绝对症状严重程度水平。本研究使用经过验证的结局工具将CT扫描结果与基于患者主观的结局（症状评分）联系起来。
