学龄儿童失配负波的成熟

Maturation of mismatch negativity in school-age children.

作者信息

Shafer V L, Morr M L, Kreuzer J A, Kurtzberg D

机构信息

Program in Speech and Hearing Sciences, The Graduate Center, City University of New York, New York, USA.

出版信息

Ear Hear. 2000 Jun;21(3):242-51. doi: 10.1097/00003446-200006000-00008.

DOI:10.1097/00003446-200006000-00008

PMID:10890733

Abstract

OBJECTIVE

Event-related potentials were recorded to investigate the maturation of auditory processing in school-age children.

DESIGN

The mismatch negativity (MMN) was obtained in an oddball tone discrimination paradigm in 66 school-age children and 12 adults. In the children's data, a prominent negativity to both the standard and deviant tone, peaking around 200 msec, was observed, and compared with the N1 auditory evoked potential component.

RESULTS

The MMN was found to decrease with latency by 11 msec/yr from 4 to 10 yr of age. No developmental change in MMN amplitude was seen from 4 to 10 yr of age. However, the MMN amplitude was significantly smaller in adults than in children. The prominent negativity in children was significantly later than the adult N1 component, and did not change in latency from 4 to 10 yr of age. This finding adds to a body of evidence suggesting that this prominent negativity and the adult N1 are not the same component. The magnitude of the prominent negativity in children decreased slightly with age.

CONCLUSION

Changes in the timing of the brain discriminative response, MMN, suggest systematic maturational changes in auditory processing.

摘要

目的

记录事件相关电位以研究学龄儿童听觉加工的成熟情况。

设计

在66名学龄儿童和12名成年人中采用oddball音调辨别范式获取失匹配负波（MMN）。在儿童数据中，观察到对标准音调和偏差音调均出现一个明显的负波，在约200毫秒时达到峰值，并与N1听觉诱发电位成分进行比较。

结果

发现4至10岁儿童的MMN潜伏期以每年11毫秒的速度缩短。4至10岁儿童的MMN波幅未见发育性变化。然而，成年人的MMN波幅显著小于儿童。儿童中明显的负波潜伏期显著晚于成年人的N1成分，且4至10岁时潜伏期未发生变化。这一发现进一步证明该明显负波与成年人的N1并非同一成分。儿童中明显负波的幅度随年龄略有下降。