Korpilahti P, Lang H A
Centre for Cognitive Neuroscience, University of Turku, Finland.
Electroencephalogr Clin Neurophysiol. 1994 Oct;91(4):256-64. doi: 10.1016/0013-4694(94)90189-9.
Auditory event-related potentials (ERPs) and especially the mismatch negativity component (MMN) were examined in 14 dysphasic and 12 normal children (aged 7-13). The ERPs were elicited by sine tone stimuli using the passive oddball paradigm and short ISI (350 msec). We measured the peak latency and peak amplitude of MMN responses to frequency (500/553 Hz) and duration (50/110 msec or 50/500 msec) differences. In the dysphasic group the peak amplitude of the frequency MMN was significantly attenuated. The duration MMN showed a significant difference between the two groups only for stimuli with highly contrasting values (50/500 msec). In normal subjects we found a negative correlation between the peak latency of the frequency MMN and age. The maturational changes of long-latency ERPs were non-significant in dysphasic children. Evidence of differences in hemispheric asymmetry between the two groups was observed.
对14名言语障碍儿童和12名正常儿童（7 - 13岁）进行了听觉事件相关电位（ERP）检查，尤其对失匹配负波成分（MMN）进行了检测。使用被动式奇偶数范式和短刺激间隔（350毫秒），通过正弦音调刺激诱发ERP。我们测量了MMN对频率（500/553赫兹）和时长（50/110毫秒或50/500毫秒）差异的峰值潜伏期和峰值幅度。在言语障碍组中，频率MMN的峰值幅度显著衰减。仅对于具有高对比度值（50/500毫秒）的刺激，时长MMN在两组之间显示出显著差异。在正常受试者中，我们发现频率MMN的峰值潜伏期与年龄呈负相关。言语障碍儿童中长潜伏期ERP的成熟变化不显著。观察到两组之间半球不对称性存在差异的证据。
