Ayala C, Blackwell K E
Department of Surgery, University of California Los Angeles School of Medicine 90095, USA.
Laryngoscope. 1999 Feb;109(2 Pt 1):259-65. doi: 10.1097/00005537-199902000-00016.
To determine the incidence of perioperative protein C deficiency in patients undergoing free flap reconstruction of cancer-related defects in the head and neck.
Prospective case series.
Ten patients underwent microvascular reconstruction after surgical therapy of carcinomas of the oral cavity or oropharynx. Coagulation studies were determined in all patients 72 hours after surgery.
Academic tertiary care medical center
Protein C deficiency was detected in 70% of patients. One free flap failure was attributed to protein C deficiency.
Vitamin K-dependent clotting factors are frequently deficient during the postoperative period after major head and neck surgery, which may result in a state of hypercoagulability. Protein C deficiency should be considered as a possible cause of free flap thrombosis in patients who undergo microvascular head and neck reconstruction.
确定头颈部癌症相关缺损游离皮瓣重建患者围手术期蛋白C缺乏症的发生率。
前瞻性病例系列研究。
10例患者在接受口腔或口咽癌手术治疗后进行微血管重建。术后72小时对所有患者进行凝血研究。
学术性三级医疗中心
70%的患者检测到蛋白C缺乏。1例游离皮瓣失败归因于蛋白C缺乏。
在头颈部大手术后的术后期间，维生素K依赖的凝血因子经常缺乏，这可能导致高凝状态。对于接受微血管头颈部重建的患者，蛋白C缺乏应被视为游离皮瓣血栓形成的可能原因。
