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1
Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences.小鼠细胞中8-氧代鸟嘌呤的转录偶联修复：ogg1蛋白是修复非转录序列所必需的，但不是转录序列所必需的。
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8397-402. doi: 10.1073/pnas.140137297.
2
Repair of 8-oxoguanine and Ogg1-incised apurinic sites in a CHO cell line.在一个中国仓鼠卵巢细胞系中8-氧代鸟嘌呤和Ogg1切割的脱嘌呤位点的修复
Prog Nucleic Acid Res Mol Biol. 2001;68:95-105. doi: 10.1016/s0079-6603(01)68092-9.
3
Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice.7,8-二氢-8-氧代鸟嘌呤-DNA糖基化酶（Ogg1）缺陷小鼠中与年龄相关和组织特异性的氧化性DNA碱基损伤积累
Carcinogenesis. 2001 Sep;22(9):1459-63. doi: 10.1093/carcin/22.9.1459.
4
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells.野生型或8-氧代鸟嘌呤DNA糖基化酶缺陷的哺乳动物和细菌细胞提取物中8-氧代鸟嘌呤:胞嘧啶、8-氧代鸟嘌呤:腺嘌呤、腺嘌呤:胞嘧啶和胞嘧啶:胞嘧啶DNA修复的比较分析。
DNA Repair (Amst). 2003 Jun 11;2(6):707-18. doi: 10.1016/s1568-7864(03)00041-7.
5
Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.酿酒酵母OGG1基因在大肠杆菌中的克隆与表达，该基因编码一种DNA糖基化酶，可切除7,8-二氢-8-氧代鸟嘌呤和2,6-二氨基-4-羟基-5-N-甲基甲酰胺基嘧啶。
Proc Natl Acad Sci U S A. 1996 May 28;93(11):5197-202. doi: 10.1073/pnas.93.11.5197.
6
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.用于修复8-氧代鸟嘌呤的多种DNA糖基化酶及其体内潜在功能。
Prog Nucleic Acid Res Mol Biol. 2001;68:193-205. doi: 10.1016/s0079-6603(01)68100-5.
7
Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair.AP核酸内切酶对人8-氧代鸟嘌呤-DNA糖基化酶的刺激作用：碱基切除修复起始步骤的潜在协同作用
Nucleic Acids Res. 2001 Jan 15;29(2):430-8. doi: 10.1093/nar/29.2.430.
8
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.人类碱基切除修复酶对含有7,8-二氢-8-氧代鸟嘌呤和无碱基位点的DNA的相反碱基依赖性反应。
EMBO J. 1997 Oct 15;16(20):6314-22. doi: 10.1093/emboj/16.20.6314.
9
Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.OGG1失活会增加酿酒酵母中G.C→T.A颠换的发生率：真核细胞中DNA存在内源性氧化损伤的证据。
Mol Gen Genet. 1997 Mar 26;254(2):171-8. doi: 10.1007/s004380050405.
10
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.线粒体DNA中8-氧代脱氧鸟苷损伤的修复依赖于氧代鸟嘌呤DNA糖基化酶（OGG1）基因，并且8-氧代鸟嘌呤在OGG1缺陷小鼠的线粒体DNA中积累。
Cancer Res. 2001 Jul 15;61(14):5378-81.

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Promoter dependent RNA polymerase II bypass of the epimerizable DNA lesion, Fapy•dG and 8-Oxo-2'-deoxyguanosine.启动子依赖性 RNA 聚合酶 II 绕过可互变异构的 DNA 损伤，Fapy•dG 和 8-氧代-2'-脱氧鸟苷。
Nucleic Acids Res. 2024 Jul 22;52(13):7437-7446. doi: 10.1093/nar/gkae529.
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Acquired resistance to irradiation or docetaxel is not associated with cross-resistance to cisplatin in prostate cancer cell lines.在前列腺癌细胞系中，获得性对辐射或多西紫杉醇的耐药性与顺铂的交叉耐药性无关。
J Cancer Res Clin Oncol. 2022 Jun;148(6):1313-1324. doi: 10.1007/s00432-022-03914-5. Epub 2022 Jan 12.
3
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.可遗传的氧化 DNA 碱基修复模式与修复复合物预先靶向开放染色质一致。
Nucleic Acids Res. 2021 Jan 11;49(1):221-243. doi: 10.1093/nar/gkaa1120.
4
Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters.鸟嘌呤氧化与基因启动子中 G-四链体折叠的相互作用。
J Am Chem Soc. 2020 Jan 22;142(3):1115-1136. doi: 10.1021/jacs.9b11050. Epub 2020 Jan 9.
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8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On-Off Switch for Transcription.基因启动子G-四链体背景下的8-氧代-7,8-二氢鸟嘌呤是转录的开关。
ACS Chem Biol. 2017 Sep 15;12(9):2417-2426. doi: 10.1021/acschembio.7b00636. Epub 2017 Aug 28.
6
8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.8-氧代鸟嘌呤DNA糖基化酶（OGG1）缺乏会引发肌肉中脂质和线粒体代谢的协同变化。
PLoS One. 2017 Jul 20;12(7):e0181687. doi: 10.1371/journal.pone.0181687. eCollection 2017.
7
Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress.锥虫昆虫和哺乳动物生命周期形式中MSH2突变导致的不同表型与寄生虫对氧化应激的适应性相关。
PLoS Negl Trop Dis. 2015 Jun 17;9(6):e0003870. doi: 10.1371/journal.pntd.0003870. eCollection 2015 Jun.
8
8-Hydroxyguanine: From its discovery in 1983 to the present status.8-羟基鸟嘌呤：从 1983 年的发现到现在的状况。
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9
Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability.氧化应激和 DNA 损伤：8-氧鸟嘌呤损伤在克氏锥虫细胞活力中的作用。
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10
The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis.碱基切除修复基因 OGG1、APN1 和 APN2 在苯并[a]芘-7,8-二酮诱导的 p53 突变中的作用。
Mutat Res. 2013 Jan 20;750(1-2):121-8. doi: 10.1016/j.mrgentox.2012.10.003. Epub 2012 Oct 29.

本文引用的文献

1
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.8-氧代鸟嘌呤的转录偶联修复：对XPG、TFIIH和CSB的需求及其对科凯恩综合征的影响
Cell. 2000 Apr 14;101(2):159-71. doi: 10.1016/s0092-8674(00)80827-2.
2
Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice.Mmh/Ogg1基因失活导致小鼠体内8-羟基鸟嘌呤积累。
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61. doi: 10.1073/pnas.050404497.
3
Quality control by DNA repair.通过DNA修复进行质量控制。
Science. 1999 Dec 3;286(5446):1897-905. doi: 10.1126/science.286.5446.1897.
4
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.在清除氧化性碱基损伤存在缺陷的小鼠中，前诱变DNA损伤的积累。
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5. doi: 10.1073/pnas.96.23.13300.
5
MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae.在酿酒酵母中，去除与8-氧代鸟嘌呤错配的腺嘌呤需要MSH2和MSH6。
Mol Cell. 1999 Sep;4(3):439-44. doi: 10.1016/s1097-2765(00)80346-9.
6
Overexpression of Ogg1 in mammalian cells: effects on induced and spontaneous oxidative DNA damage and mutagenesis.Ogg1在哺乳动物细胞中的过表达：对诱导性和自发性氧化性DNA损伤及诱变的影响。
Carcinogenesis. 1999 Sep;20(9):1863-8. doi: 10.1093/carcin/20.9.1863.
7
Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.由选择性剪接的OGG1 mRNA编码的两种主要形式的人8-氧代鸟嘌呤DNA糖基化酶的表达及细胞内差异定位
Mol Biol Cell. 1999 May;10(5):1637-52. doi: 10.1091/mbc.10.5.1637.
8
Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress.8-羟基鸟嘌呤的碱基切除修复可保护DNA免受内源性氧化应激的损伤。
Biochimie. 1999 Jan-Feb;81(1-2):59-67. doi: 10.1016/s0300-9084(99)80039-x.
9
Excision repair of 8-hydroxyguanine in mammalian cells: the mouse Ogg1 protein as a model.哺乳动物细胞中8-羟基鸟嘌呤的切除修复：以小鼠Ogg1蛋白为模型
Free Radic Res. 1998 Dec;29(6):487-97. doi: 10.1080/10715769800300541.
10
Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae.酿酒酵母中的自发突变、氧化性DNA损伤以及碱基切除修复和核苷酸切除修复的作用。
Yeast. 1999 Feb;15(3):205-18. doi: 10.1002/(SICI)1097-0061(199902)15:3<205::AID-YEA361>3.0.CO;2-1.

小鼠细胞中8-氧代鸟嘌呤的转录偶联修复：ogg1蛋白是修复非转录序列所必需的，但不是转录序列所必需的。

Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences.

作者信息

Le Page F, Klungland A, Barnes D E, Sarasin A, Boiteux S

机构信息

Laboratoire de Radiobiologie de l'ADN, UMR217, Commissariat à l'Energie Atomique-Centre National de la Recherche Scientifique, BP6, 92265-Fontenay aux Roses, France.

出版信息

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8397-402. doi: 10.1073/pnas.140137297.

DOI:10.1073/pnas.140137297
PMID:10890888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC26959/
Abstract

To assess the role of the Ogg1 DNA glycosylase in the transcription-coupled repair (TCR) of the mutagenic lesion, 7, 8-dihydro-8oxoguanine (8-OxoG), we have investigated the removal of this lesion in wild-type and ogg1(-/-) null mouse embryo fibroblast (MEF) cell lines. We used nonreplicating plasmids containing a single 8-OxoG.C base pair in a different assay that allowed us to study the removal of 8-OxoG located in a transcribed sequence (TS) or in a nontranscribed sequence (NTS). The results show that the removal of 8-OxoG in a wild-type MEF cell line is faster in the TS than in the NTS, indicating TCR of 8-OxoG in murine cells. In the homozygous ogg1(-/-) MEF cell line, 8-OxoG was not removed from the NTS whereas there was still efficient 8-OxoG repair in the TS. Expression of the mouse Ogg1 protein in the homozygous ogg1(-/-) cell line restored the ability to remove 8-OxoG in the NTS. Therefore, we have demonstrated that Ogg1 is essential for the repair of 8-OxoG in the NTS but is not required in the TS. These results indicate the existence of an Ogg1-independent pathway for the TCR of 8-OxoG in vivo.

摘要

为了评估Ogg1 DNA糖基化酶在诱变损伤7,8 - 二氢 - 8 - 氧代鸟嘌呤（8 - OxoG）的转录偶联修复（TCR）中的作用，我们研究了野生型和ogg1(-/-)基因敲除小鼠胚胎成纤维细胞（MEF）系中该损伤的去除情况。我们在不同的实验中使用了含有单个8 - OxoG.C碱基对的非复制性质粒，这使我们能够研究位于转录序列（TS）或非转录序列（NTS）中的8 - OxoG的去除情况。结果表明，野生型MEF细胞系中TS区域的8 - OxoG去除速度比NTS区域快，这表明小鼠细胞中存在8 - OxoG的TCR。在纯合ogg1(-/-) MEF细胞系中，NTS区域的8 - OxoG没有被去除，而TS区域仍有高效的8 - OxoG修复。在纯合ogg1(-/-)细胞系中表达小鼠Ogg1蛋白恢复了去除NTS区域8 - OxoG的能力。因此，我们证明了Ogg1对于NTS区域8 - OxoG的修复至关重要，但在TS区域则不是必需的。这些结果表明体内存在一条不依赖Ogg1的8 - OxoG的TCR途径。