Yoshimoto Y, Moridera K, Imura H
N Engl J Med. 1975 Jan 30;292(5):242-5. doi: 10.1056/NEJM197501302920505.
To elucidate whether diminished pituitary gonadotropin reserve can be restored by repeated stimulation with luteinizing-hormone-releasing hormone, plasma luteinizing hormone and follicly-stimulating hormone responses were studied before and after daily intravenous infusion of 400 mug of luteinizing-hormone-releasing hormone for two to 23 days, in patients with hypogonadotropic hypogonadism of various causes. In five of nine patients with isolated gonadotropin deficiency, the impaired plasma luteinizing hormone response was restored to normal after treatment for seven days or more, whereas it was unchanged in four patients treated for less than five days. However, six patients with anorexia nervosa regained normal responses after three to five days' treatment. Five of nine patients with organic hypothalamopituitary lesions also showed normal responsiveness after five to seven days' treatment. These results suggest that the response to the test after repeated administration of luteinizing-hormone-releasing hormone is of value for the diagnosis of hypogonadism of hypothalamic origin.
为了阐明通过促黄体生成素释放激素反复刺激能否恢复垂体促性腺激素储备减少的情况，我们对各种原因导致的性腺功能减退性性腺功能减退患者，在每日静脉输注400微克促黄体生成素释放激素持续2至23天之前和之后，研究了血浆促黄体生成素和促卵泡生成素的反应。在9例孤立性促性腺激素缺乏患者中的5例，经过7天或更长时间治疗后，受损的血浆促黄体生成素反应恢复正常，而在治疗少于5天的4例患者中则无变化。然而，6例神经性厌食症患者在治疗3至5天后恢复了正常反应。9例器质性下丘脑 - 垂体病变患者中的5例在治疗5至7天后也显示出正常反应性。这些结果表明，反复给予促黄体生成素释放激素后对该试验的反应对于诊断下丘脑源性性腺功能减退有价值。
