Secretion of basal gonadotropins after LRH decapeptide and tripeptide. Stimulation in hypogonadotropic hypogonadism.

Sixteen females with pubertary delay of the isolated hypogonadotropic hypogonadism type (mean age 19 years, age range 14-25 years) were studied by radioimmunoassay of LH and FSH. The mean values +/- SE were compared to the values obtained from 10 girls in the B 5 Tanner stage and 15 normal adult women investigated on the 14th and 21st day of their ovarian cycle. Two females were given the LRH decapeptide and LRH-LA tripeptide stimulation test. In one case the daily variations of circulating serum LH and FSH were followed up. The fluctuations found suggest an ovarian rhythm which is present in the normal adult woman.