Serra G B, Muscatello P, Menini E, Lafuenti G, Caniglia R
Obstet Gynecol. 1975 May;45(5):523-6.
Although the absence of pituitary response to the luteinizing hormone releasing hormone (LHRH) test has been considered proof of a lesion primarily localized at the pituitary level, the possibility exists that an absent pituitary response may represent only the effect of a chronic deficiency of hypothalamic secretion. To verify this hypothesis, 4 patients with primary amenorrhea, hypogonadotropic hypogonadism, and deficient or absent responses to a 25 mug LHRH rapid IV test were treated with 400 mug LHRH infused in 7 hours during each of 3 successive days. The finding that patients with deficient LH responses to a rapid LHRH test became normally responsive to a second equivalent test after a slow and prolonged treatment with the decapeptide suggests that, in these patients, besides a lesion at the pituitary level, a primary defect at the hypothalamic or higher centers may also be suspected.
尽管垂体对促黄体生成素释放激素（LHRH）试验无反应一直被视为病变主要局限于垂体水平的证据，但垂体无反应可能仅代表下丘脑分泌长期不足的影响。为验证这一假设，对4例原发性闭经、低促性腺激素性性腺功能减退且对25微克LHRH快速静脉试验反应不足或无反应的患者，在连续3天的每一天中，于7小时内输注400微克LHRH进行治疗。对快速LHRH试验LH反应不足的患者，在用十肽进行缓慢而持久的治疗后，对第二次等量试验变得正常反应，这一发现表明，在这些患者中，除垂体水平的病变外，还可能怀疑下丘脑或更高中枢存在原发性缺陷。
