Czinner E, Kéry A, Hagymási K, Blázovics A, Lugasi A, Szöke E, Lemberkovics E
Institute of Pharmacognosy, Semmelweis University, Budapest, Hungary.
Eur J Drug Metab Pharmacokinet. 1999 Oct-Dec;24(4):309-13. doi: 10.1007/BF03190038.
The biologically important components of Helichrysum arenarium (L.) Moench are the flavonoids, which may have choleretic, hepatoprotective and antimicrobial properties. During our study, we examined the flavonoids present in the lyophilizate of the inflorescence of Helichrysum arenarium (L.) Moench (Helichrysi flos, syn. Stoechados flos) and in the tea made from the inflorescence via qualitative and quantitative analysis, and determined the flavonoid content. We examined the properties of the lyophilizate antioxidant, and measured the H-donor activity, reducing power property and total scavenger capacity via spectrophotometric and chemiluminescent methods. We compared the results with those of the agent present in milk thistle (Silybum marianum L.), the silibinin flavonoid. Regarding the H-donor activity, our lyophilizate was determined to be more effective than the silibinin at the same amounts; on the other hand, its reducing power property and total scavenger capacity was lower than that of silibinin. The flavonoid content, which is responsible for the lyophilizate effect, was found to be 0.47% according to our measurements; it is, therefore, possible that an extract with such a concentration of flavonoids may be of therapeutic benefit.
沙生蜡菊（Helichrysum arenarium (L.) Moench）的重要生物活性成分是黄酮类化合物，它们可能具有利胆、保肝和抗菌特性。在我们的研究中，我们通过定性和定量分析，检测了沙生蜡菊（Helichrysum arenarium (L.) Moench）（蜡菊花，同物异名Stoechados flos）花序冻干物以及由该花序制成的茶中所含的黄酮类化合物，并测定了黄酮类化合物的含量。我们检测了冻干物的抗氧化性能，并通过分光光度法和化学发光法测量了其氢供体活性、还原能力和总清除能力。我们将结果与水飞蓟（Silybum marianum L.）中的水飞蓟宾黄酮类化合物的结果进行了比较。关于氢供体活性，我们的冻干物在相同用量下比水飞蓟宾更有效；另一方面，其还原能力和总清除能力低于水飞蓟宾。根据我们的测量，导致冻干物产生效果的黄酮类化合物含量为0.47%；因此，含有这种黄酮类化合物浓度的提取物可能具有治疗益处。
