Wamboldt M Z, Hewitt J K, Schmitz S, Wamboldt F S, Räsänen M, Koskenvuo M, Romanov K, Varjonen J, Kaprio J
National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
Am J Med Genet. 2000 Apr 3;96(2):146-53. doi: 10.1002/(sici)1096-8628(20000403)96:2<146::aid-ajmg4>3.0.co;2-j.
Clinical studies have shown a relationship between allergic disorders and depression, panic disorder, attention deficit/hyperactivity disorder, and social anxiety for a significant subset of patients with these disorders. The nature of the relationship, whether due to shared environmental or biologic vulnerabilities or as a result of the stress of chronic illness, has been less clear. By examining the covariance of atopic disorders and depressive symptoms in a community sample of monozygotic (MZ) and dizygotic (DZ) twins, the contribution of genetic and/or shared environmental etiological factors can be established. A Finnish sample of 1337 MZ and 2506 DZ twin pairs, ages 33-60 years, was sent questionnaires inquiring about history of asthma, eczema, and atopic rhinitis, as well as the Beck Depression Inventory (BDI). The nature of the covariation between twins of these symptoms was investigated by fitting competing genetic and environmental models. Within-person correlation between atopic symptoms and BDI was 0.103 (P < 0.001) for the total sample. Using the Mx statistical modeling program to fit the data to competing quantitative genetic models, the best fitting model estimated that 64% of the association between atopy and BDI was due to shared familial vulnerability, primarily additive genetic influences. Although the measures for allergic disorders and depression are crude, this study supports the hypothesis that there is a small shared genetic risk for atopic and depressive symptoms, and if replicated, may open research for common mechanisms between allergic and depressive disorders. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:146-153, 2000.
临床研究表明，对于患有过敏性疾病的相当一部分患者，这些疾病与抑郁症、恐慌症、注意力缺陷/多动障碍以及社交焦虑症之间存在关联。这种关联的本质，无论是由于共同的环境或生物易感性，还是慢性病压力的结果，一直不太明确。通过在单卵（MZ）和双卵（DZ）双胞胎的社区样本中检查特应性疾病和抑郁症状的协方差，可以确定遗传和/或共同环境病因因素的作用。向芬兰的1337对MZ和2506对DZ双胞胎（年龄在33至60岁之间）发送了问卷，询问哮喘、湿疹和特应性鼻炎病史以及贝克抑郁量表（BDI）。通过拟合相互竞争的遗传和环境模型，研究了这些症状在双胞胎之间的协变性质。总样本中特应性症状与BDI的个体内相关性为0.103（P < 0.001）。使用Mx统计建模程序将数据拟合到相互竞争的定量遗传模型，最佳拟合模型估计特应性与BDI之间64%的关联归因于共同的家族易感性，主要是加性遗传影响。尽管用于过敏性疾病和抑郁症的测量方法较为粗略，但这项研究支持了这样一种假设，即特应性和抑郁症状存在小的共同遗传风险，如果得到重复验证，可能会开启对过敏性和抑郁性疾病共同机制的研究。《美国医学遗传学杂志》（神经精神遗传学）96:146 - 153，2000年。
