NCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
NCRR-The National Centre for Register-based Research, Aarhus University, Aarhus, Denmark; iPSYCH-Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Brain Behav Immun. 2020 Oct;89:433-439. doi: 10.1016/j.bbi.2020.07.030. Epub 2020 Jul 28.
Major depression and asthma frequently co-occur, suggesting shared genetic vulnerability between these two disorders. We aimed to determine whether a higher genetic liability to major depression was associated with increased childhood asthma risk, and if so, whether such an association differed by sex of the child.
We conducted a population-based cohort study comprising 16,687 singletons born between 1991 and 2005 in Denmark. We calculated the polygenic risk score (PRS) for major depression as a measure of genetic liability based on the summary statistics from the Major Depressive Disorder Psychiatric Genomics Consortium collaboration. The outcome was incident asthma from age 5 to 15 years, identified from the Danish National Patient Registry and the Danish National Prescription Registry. Stratified Cox regression was used to analyze the data.
Greater genetic liability to major depression was associated with an increased asthma risk with a hazard ratio (HR) of 1.06 (95% CI: 1.01-1.10) per standard deviation increase in PRS. Children in the highest major depression PRS quartile had a HR for asthma of 1.20 (95% CI: 1.06-1.36), compared with children in the lowest quartile. However, major depression PRS explained only 0.03% of asthma variance (Pseudo-R). The HRs of asthma by major depression PRS did not differ between boys and girls.
Our results suggest a shared genetic contribution to major depression and childhood asthma, and there is no evidence of a sex-specific difference in the association.
重度抑郁症和哮喘常同时发生，提示这两种疾病之间存在共同的遗传易感性。我们旨在确定对重度抑郁症的遗传易感性增加是否与儿童哮喘风险增加相关，以及如果存在这种关联，其是否因儿童的性别而异。
我们进行了一项基于人群的队列研究，纳入了 1991 年至 2005 年期间在丹麦出生的 16687 名单胎儿童。我们根据重度抑郁症精神遗传学联合会的汇总统计数据，计算了重度抑郁症的多基因风险评分（PRS），作为遗传易感性的衡量标准。结果是 5 至 15 岁时的新发哮喘，通过丹麦国家患者登记处和丹麦国家处方登记处确定。采用分层 Cox 回归分析数据。
对重度抑郁症的遗传易感性增加与哮喘风险增加相关，PRS 每增加一个标准差，哮喘的风险比（HR）为 1.06（95%CI：1.01-1.10）。在最高的重度抑郁症 PRS 四分位组中，儿童哮喘的 HR 为 1.20（95%CI：1.06-1.36），而在最低的四分位组中，儿童哮喘的 HR 为 1.06（95%CI：1.01-1.10）。然而，重度抑郁症 PRS 仅解释了哮喘方差的 0.03%（伪 R）。重度抑郁症 PRS 与哮喘的 HR 在男孩和女孩之间没有差异。
我们的结果表明，重度抑郁症和儿童哮喘存在共同的遗传贡献，并且这种关联没有性别特异性差异的证据。
