Horlick M, Thornton J, Wang J, Levine L S, Fedun B, Pierson R N
Body Composition Unit, St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
J Bone Miner Res. 2000 Jul;15(7):1393-7. doi: 10.1359/jbmr.2000.15.7.1393.
Previous reports of gender and ethnic differences in bone mineral in prepubertal children have been inconsistent due to different methodologies, the problematic nature of bone density by dual-energy X-ray absorptiometry (DXA) calculated as the ratio of bone mineral mass to projected bone area (BA), and the generally small study populations. The aim of this study was to test the hypothesis that gender and ethnic differences in bone mineral by DXA are present in prepubertal children. The subjects were 336 healthy Asian, black, and white prepubertal children (172 females and 164 males). Total body bone mineral content (TBBMC) was adjusted for total body BA (TBBA), age, height, and weight. Adjusted mean TBBMC was greater in males than in females (p = 0.01). The gender difference was independent of ethnicity. Adjusted mean TBBMC was different for black compared with nonblack children (p = 0.001). The ethnic difference was a function of TBBA and weight. This study in a multiethnic population of prepubertal children shows (1) a gender difference in TBBMC and (2) an ethnic difference in TBBMC.
先前有关青春期前儿童骨矿物质性别和种族差异的报告结果并不一致，原因在于方法不同、双能X线吸收法（DXA）计算的骨密度存在问题（骨矿物质质量与投影骨面积之比）以及研究人群普遍规模较小。本研究的目的是验证青春期前儿童存在DXA测量的骨矿物质性别和种族差异这一假设。研究对象为336名健康的亚洲、黑人及白人青春期前儿童（172名女性和164名男性）。全身骨矿物质含量（TBBMC）针对全身骨面积（TBBA）、年龄、身高和体重进行了校正。校正后的TBBMC均值男性高于女性（p = 0.01）。性别差异与种族无关。黑人儿童与非黑人儿童相比，校正后的TBBMC均值不同（p = 0.001）。种族差异是TBBA和体重的函数。这项针对多民族青春期前儿童群体的研究表明：（1）TBBMC存在性别差异；（2）TBBMC存在种族差异。
