Brase S, Dahmen S
RWTH Aachen, Institut fur Organische Chemie, Germany.
Chemistry. 2000 Jun 2;6(11):1899-905. doi: 10.1002/1521-3765(20000602)6:11<1899::aid-chem1899>3.0.co;2-m.
Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer-bound molecules, which can be cleaved from the resin leaving no residual functionality to bias the library. Various approaches based on different Group 14 to Group 16 heteroatoms have been developed in the past and used in new syntheses of diverse compound libraries.
无痕连接子能够将芳烃和烷烃连接到聚合物载体上,近年来受到了越来越多的关注。这些锚定基团允许对聚合物结合的分子进行化学转化,这些分子可以从树脂上裂解下来,不会留下残留官能团影响文库。过去已经开发了基于不同第14族到第16族杂原子的各种方法,并用于各种化合物文库的新合成中。