Recent advances in traceless linkers.

The use of solid-phase organic synthesis for the preparation of small molecule compound libraries has been the driving force behind the development of new linkers and reaction technologies. Traceless linkers afford targets in which it is not readily apparent where the original point of attachment to the solid support had been. In many cases the site of linker attachment has been replaced with a hydrogen atom. This brief review summarizes some of the advances during the past several years involving traceless linkers in solid-phase organic synthesis.