Pardi D S, Tremaine W J, Sandborn W J, Loftus E V, Poland G A, Harmsen W S, Zinsmeister A R, Melton L J
Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Am J Gastroenterol. 2000 Jun;95(6):1480-5. doi: 10.1111/j.1572-0241.2000.02082.x.
The measles virus has been implicated as a possible etiological agent in the development of inflammatory bowel disease (IBD). Measles infection at an early age is associated with subacute sclerosing panencephalitis, a degenerative neurological condition caused by persistent measles infection of the central nervous system. We sought to determine whether infection with measles virus at an early age was also associated with an increased risk of developing IBD.
Patients with measles infection diagnosed before the age of 5 yr were identified through the diagnostic indices of the Mayo Clinic and the Rochester Epidemiology Project. A questionnaire was used to ascertain a subsequent history of IBD, which was confirmed by records from the subjects' physicians. The risks of developing Crohn's disease and ulcerative colitis were calculated relative to expected rates for these conditions in the Olmsted County, Minnesota population.
Of 1164 eligible cases, 662 (57%) completed the questionnaire. There were six confirmed cases of Crohn's disease and six of ulcerative colitis. The expected number of cases was 1.9 for Crohn's disease (standardized incidence ratio [SIR] 3.1, 95% confidence interval [CI] 1.1-6.8) and 2.0 for ulcerative colitis (SIR 3.0, CI 1.1-6.5). There was a trend towards a higher risk of developing IBD with an earlier age of infection.
Early measles infection is associated with an increased risk of developing Crohn's disease and ulcerative colitis. The risk may be higher with earlier infection.
麻疹病毒被认为可能是炎症性肠病（IBD）发病的病因。早年感染麻疹与亚急性硬化性全脑炎相关，这是一种由中枢神经系统持续性麻疹感染引起的退行性神经疾病。我们试图确定早年感染麻疹病毒是否也与患IBD的风险增加有关。
通过梅奥诊所的诊断指标和罗切斯特流行病学项目确定5岁前被诊断为麻疹感染的患者。使用问卷调查来确定随后的IBD病史，并由受试者医生的记录予以证实。相对于明尼苏达州奥尔姆斯特德县人群中这些疾病的预期发病率，计算患克罗恩病和溃疡性结肠炎的风险。
在1164例符合条件的病例中，662例（57%）完成了问卷调查。确诊克罗恩病6例，溃疡性结肠炎6例。克罗恩病的预期病例数为1.9（标准化发病率[SIR]3.1，95%置信区间[CI]1.1 - 6.8），溃疡性结肠炎为2.0（SIR 3.0，CI 1.1 - 6.5）。感染年龄越小，患IBD的风险有越高的趋势。
早年感染麻疹与患克罗恩病和溃疡性结肠炎的风险增加有关。感染越早，风险可能越高。
