Richler Jennifer, Luyster Rhiannon, Risi Susan, Hsu Wan-Ling, Dawson Geraldine, Bernier Raphael, Dunn Michelle, Hepburn Susan, Hyman Susan L, McMahon William M, Goudie-Nice Julie, Minshew Nancy, Rogers Sally, Sigman Marian, Spence M Anne, Goldberg Wendy A, Tager-Flusberg Helen, Volkmar Fred R, Lord Catherine
University of Michigan, Ann Arbor, 48109-2054, USA.
J Autism Dev Disord. 2006 Apr;36(3):299-316. doi: 10.1007/s10803-005-0070-1.
A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.
一项针对351名自闭症谱系障碍（ASD）儿童和31名发育正常儿童的多中心研究，通过对照顾者的访谈来描述儿童早期社交沟通里程碑的获得和丧失情况。对于大多数经历过倒退的ASD儿童来说，倒退前的发育明显异常。与未经历倒退的ASD儿童相比，丧失技能的儿童在言语智商和社交互动方面的表现也略差，自闭症症状的平均发病年龄较晚，且胃肠道症状更多。没有证据表明自闭症症状或倒退的发作与麻疹-腮腺炎-风疹疫苗接种有关。本文讨论了这些发现对ASD“倒退型表型”存在的影响。
