van't Hof M A, Haschke F
Department of Paediatrics, University of Vienna, Austria.
J Pediatr Gastroenterol Nutr. 2000;31 Suppl 1:S48-59. doi: 10.1097/00005176-200007001-00005.
Fully longitudinal data from the multicenter Euro-Growth study (21 study sites; n = 2145 children) were used to develop sex-specific percentiles and Z-scores for body mass index (BMI) and weight for length (WfL) during the first 36 months of life.
Smoothed percentile curves for BMI against age were constructed and checked against raw percentiles. Smoothed percentile curves for WfL were constructed according to established procedures and were checked against raw percentiles. The relation of BMI with length and of WfL with age was examined. The relation between BMI and WfL was tested using z-scores of each. The influence of gender, geographic location (study site), and genetic factors on BMI and WfL was examined. Finally, the new references for BMI and WfL were compared with other published references.
Selected percentiles (P; P3, P5, P10, P25, P50, P75, P90, P95, and P97) for BMI showed a sharp increase from 1 to 6 months of age and a gradual decline between 12 and 36 months. Smoothed percentiles for WfL showed only small deviations from raw percentiles. BMI was found to be essentially independent of length, whereas WfL showed some degree of dependence on age. Values for BMI and WfL showed very good agreement, except at the extremes of the age range. A modest degree of influence of geographic location on BMI and WfL was found. Correlations with parental BMI and WfL were very weak, however. Comparison with the National Center for Health Statistics (NCHS) references showed the latter to have a narrower range of values.
The new Euro-Growth references for BMI and WfL provide improved tools for health workers and researchers dealing with childhood obesity.
来自多中心欧洲生长研究（21个研究地点；n = 2145名儿童）的完全纵向数据被用于制定出生后头36个月内体重指数（BMI）和身长体重（WfL）的性别特异性百分位数和Z评分。
构建了BMI随年龄变化的平滑百分位数曲线，并与原始百分位数进行核对。根据既定程序构建了WfL的平滑百分位数曲线，并与原始百分位数进行核对。研究了BMI与身长以及WfL与年龄之间的关系。使用各自的Z评分测试了BMI与WfL之间的关系。研究了性别、地理位置（研究地点）和遗传因素对BMI和WfL的影响。最后，将BMI和WfL的新参考值与其他已发表的参考值进行了比较。
BMI的选定百分位数（P；P3、P5、P10、P25、P50、P75、P90、P95和P97）在1至6个月龄时急剧上升，在12至36个月之间逐渐下降。WfL的平滑百分位数与原始百分位数仅显示出微小差异。发现BMI基本上与身长无关，而WfL显示出一定程度的对年龄的依赖性。BMI和WfL的值显示出非常好的一致性，除了在年龄范围的极端值处。发现地理位置对BMI和WfL有适度影响。然而，与父母BMI和WfL的相关性非常弱。与美国国家卫生统计中心（NCHS）的参考值比较显示，后者的值范围更窄。
BMI和WfL的新欧洲生长参考值为处理儿童肥胖问题的卫生工作者和研究人员提供了更好的工具。
