Chetaille P, Alessi M C, Kouassi D, Morange P E, Juhan-Vague I
Laboratory of Hematology, University of Medicine La Timone, Marseille, France.
Thromb Haemost. 2000 Jun;83(6):902-5.
The Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a recently described inhibitor of fibrinolysis. The physiological variations of plasma TAFI antigen are not well known. We studied TAFI antigen values in healthy populations with a commercially available kit from Milan Analytica (Switzerland). Broad range of TAFI antigen values (from 41% to 259%) was found in a population of 249 healthy individuals. Gender as well as pregnancy did not influence mean values of TAFI antigen. There was a positive correlation between TAFI antigen and age in female (r = 0.28; p <0.05) but not in male populations. Mean TAFI antigen value of a black African male group [mean +/- SD (range): 87 +/- 23 (39-144%)] was significantly lower than the one of age matched Caucasian men [114 +/- 34 (52-259%)] (p <0.0001). TAFI antigen values were very stable within individuals, they did not significantly vary on day time or at several months period. Thus, in contrast to large inter-individual variations, TAFI antigen levels are quite stable within individuals.
凝血酶激活的纤维蛋白溶解抑制剂（TAFI）是一种最近被描述的纤维蛋白溶解抑制剂。血浆TAFI抗原的生理变化尚不清楚。我们使用来自米兰分析公司（瑞士）的商用试剂盒研究了健康人群中的TAFI抗原值。在249名健康个体组成的人群中发现了广泛的TAFI抗原值范围（从41%到259%）。性别以及妊娠均未影响TAFI抗原的平均值。女性中TAFI抗原与年龄呈正相关（r = 0.28；p <0.05），但在男性人群中无此相关性。一个非洲黑人男性组的TAFI抗原平均值[平均值±标准差（范围）：87±23（39 - 144%）]显著低于年龄匹配的白人男性组[114±34（52 - 259%）]（p <0.0001）。TAFI抗原值在个体内非常稳定，在白天或几个月的时间段内均无显著变化。因此，与个体间的巨大差异相反，TAFI抗原水平在个体内相当稳定。
