Kwinta-Rybicka J, Sancewicz-Pach K
Kliniki Nefrologii Dzieciecej Katedry Pediatrii Polsko-Amerykańskiego Instytutu Pediatrii Wydziału Lekarskiego UJ w Krakowie.
Pol Merkur Lekarski. 2000 Apr;8(46):232-4.
The study aims at assessing the results of treating lupus nephritis in 31 children, aged 4-16 years at the diagnosis of the disease. Renal biopsy was performed in 29 patients. Patients were divided into 2 groups. Group 1 included 15 children treated in 1980-92 and group 2 included 16 children treated in 1993-98. The average age, sex and follow-up were similar in both groups. All children were treated with corticosteroids. Alkylating agents were administered to 12 patients in group 1 and in 14 in group 2. Group 2 patients were given cyclophosphamide in monthly intravenous pulses, and methylprednisolone according to the Mendoza regime. In Group 1, 8 remissions (53%) were observed. Better results with more aggressive treatment were obtained in group 2--13 remissions (81%).
该研究旨在评估31名狼疮性肾炎患儿的治疗结果，这些患儿在疾病诊断时年龄为4至16岁。29例患者进行了肾活检。患者被分为两组。第一组包括1980年至1992年接受治疗的15名儿童，第二组包括1993年至1998年接受治疗的16名儿童。两组的平均年龄、性别和随访情况相似。所有儿童均接受皮质类固醇治疗。第一组12例患者和第二组14例患者使用了烷化剂。第二组患者每月静脉注射环磷酰胺脉冲，并根据门多萨方案使用甲泼尼龙。第一组观察到8例缓解（53%）。第二组采用更积极的治疗方法取得了更好的效果——13例缓解（81%）。
