Nieto Rey J, Solé Mir E, Callis Bracons L, Lara Moctezuma E, Atalá Puigbó C
Hospital Infantil Vall d'Hebron, Barcelona.
An Esp Pediatr. 1990 Nov;33(5):451-6.
We studied retrospectively 12 children with lupus nephritis divided in two groups according to the treatment made. The patients in the first group received oral 6-methyl-prednisolone alone, until children in the second received too oral cyclophosphamide. At the moment of the admission, no statistical differences were seen between both groups in terms of age, sex, clinical features, renal function, laboratory values and renal pathology based on the classification of the World Health Organisation. Patients in the second group showed a significantly better evolution in mortality (p less than 0.05), improvement of proteinuria and glomerular filtration rate (p less than 0.01 and p less than 0.05 respectively) and laboratory values, without important adverse effects. It seems that the addition of cyclophosphamide in the treatment of patients with lupus nephritis is useful to improve the prognosis of the illness in our patients.
我们回顾性研究了12例狼疮性肾炎患儿，根据所采用的治疗方法将其分为两组。第一组患儿仅接受口服6-甲基泼尼松龙治疗，直至第二组患儿也接受口服环磷酰胺治疗。入院时，根据世界卫生组织的分类，两组在年龄、性别、临床特征、肾功能、实验室检查值及肾脏病理方面均无统计学差异。第二组患儿在死亡率方面有显著更好的转归（p<0.05），蛋白尿及肾小球滤过率有改善（分别为p<0.01和p<0.05），实验室检查值也有改善，且无重要不良反应。看来在狼疮性肾炎患者的治疗中加用环磷酰胺有助于改善我们患者的疾病预后。
