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[慢性肾功能衰竭儿童及青少年幽门螺杆菌特异性IgG和IgA的患病率]

[Prevalence of Helicobacter pylori-specific IGG and IGA in children and adolescents with chronic renal failure].

作者信息

Zwolińska D, Magier K, Miler M, Szprynger K, Szczepańska M, Makulska I

机构信息

Katedry i Kliniki Nefrologii Pediatrycznej AM we Wrocławiu.

出版信息

Pol Merkur Lekarski. 2000 Apr;8(46):272-3.

Abstract

Helicobacter pylori, a bacteria first described in 1984, since that time is linked with chronic gastritis and duodenitis. Dyspeptic symptoms and chronic gastritis are common in patients with chronic renal failure (CRF). The aim of the study was to evaluate of Helicobacter pylori-specific IgG and IgA prevalence in 73 CRF children and possible link of H. pylori infection and dyspeptic symptoms. Anti-H. pylori IgG antibodies were present in 20.5% CRF children (treated conservatively--21%; on CAPD--9%; chronically hemodialysed--29.6%), IgA antibodies was present only in 3 dialysed children (4.1%). Comparing to adult CRF patient, a lower rate of H. pylori infection was observed. No correlation between H. pylori seropositivity and a presence of dyspeptic symptoms was observed. Prevalence of H. pylori antibodies was higher in older CRF children and adolescents.

摘要

幽门螺杆菌是一种于1984年首次被描述的细菌,自那时起便与慢性胃炎和十二指肠炎相关联。消化不良症状和慢性胃炎在慢性肾衰竭(CRF)患者中很常见。本研究的目的是评估73名CRF儿童中幽门螺杆菌特异性IgG和IgA的流行情况,以及幽门螺杆菌感染与消化不良症状之间的可能联系。20.5%的CRF儿童存在抗幽门螺杆菌IgG抗体(保守治疗的儿童中为21%;接受持续性非卧床腹膜透析(CAPD)的儿童中为9%;长期血液透析的儿童中为29.6%),仅3名接受透析的儿童(4.1%)存在IgA抗体。与成年CRF患者相比,幽门螺杆菌感染率较低。未观察到幽门螺杆菌血清阳性与消化不良症状的存在之间存在相关性。年龄较大的CRF儿童和青少年中幽门螺杆菌抗体的流行率较高。

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