Sugimoto H, Okada E, Hashimoto N, Suzuki S, Yoshida H, Totani Y, Ameshima S, Ishizaki T, Miyamori I
Department of Clinical Laboratory, Fukui Medical University.
Rinsho Byori. 2000 Jun;48(6):554-60.
It has been reported that serum levels of KL-6 and surfactant protein D(SP-D) can be useful indicators for interstitial pneumonia(IP). In the present study, we evaluated the clinical significance of KL-6 and SP-D by measuring the serum levels of patients with various pulmonary diseases by enzyme-linked immunosorbent assay. Serum levels of KL-6 in patients with idiopathic interstitial pneumonia(IIP), collagen disease with interstitial pneumonia(CDIP), lung cancer(LC) and LC with idiopathic interstitial pneumonia were significantly higher than of those in healthy controls. Moreover, serum levels of KL-6 were significantly higher in patients with active IP than in those with inactive IP. Serum levels of SP-D in patients with IIP and CDIP were significantly higher than of those in healthy controls. When a cut-off level of KL-6 or SP-D in sera was defined as a value of healthy controls representing the means + 2SD, the serum KL-6 positive diagnostic rate for IP(79.2%) was higher than that of SP-D(66.7%). The SP-D positive diagnostic rate for lung diseases other than IP(11.6%) was lower than that of KL-6(34.9%). The serum concentration of KL-6 in patients with the pulmonary diseases significantly correlated with that of SP-D. These findings suggest that KL-6 may be superior in the sensitivity of IP and can be used to evaluate the disease activity of IP. In addition, SP-D may be more specific for IP than KL-6.
据报道，血清KL-6和表面活性蛋白D（SP-D）水平可作为间质性肺炎（IP）的有用指标。在本研究中，我们通过酶联免疫吸附测定法测量各种肺部疾病患者的血清水平，评估了KL-6和SP-D的临床意义。特发性间质性肺炎（IIP）、伴有间质性肺炎的胶原病（CDIP）、肺癌（LC）以及伴有特发性间质性肺炎的LC患者的血清KL-6水平显著高于健康对照组。此外，活动性IP患者的血清KL-6水平显著高于非活动性IP患者。IIP和CDIP患者的血清SP-D水平显著高于健康对照组。当将血清中KL-6或SP-D的临界值定义为代表健康对照者均值+2SD的值时，IP的血清KL-6阳性诊断率（79.2%）高于SP-D（66.7%）。非IP肺部疾病的SP-D阳性诊断率（11.6%）低于KL-6（34.9%）。肺部疾病患者的血清KL-6浓度与SP-D浓度显著相关。这些发现表明，KL-6在IP的敏感性方面可能更具优势，可用于评估IP的疾病活动度。此外，SP-D对IP的特异性可能比KL-6更高。
