Department of Pharmacy, Massachusetts General Hospitalgrid.32224.35, Boston, Massachusetts, USA.
Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospitalgrid.32224.35, Boston, Massachusetts, USA.
Microbiol Spectr. 2022 Jun 29;10(3):e0038422. doi: 10.1128/spectrum.00384-22. Epub 2022 May 11.
This case series describes seven patients who received rifabutin in place of rifampin combined with conventional antimicrobial therapy for treatment of hardware-associated staphylococcal infections. Infection recurrence, defined as need for unplanned surgical intervention within the evaluable follow up period after starting rifabutin, occurred in two patients. Two patients experienced possible treatment-associated adverse effects. Findings support future work to examine rifabutin use, when rifampin is not suitable, for adjunctive treatment of staphylococcal hardware infections. This work evaluates real-world data and clinical outcomes when rifabutin is used in place of rifampin for adjunctive management of staphylococcal hardware-associated infections. This is the second case study looking at this specific use of rifabutin, signifying the current lack of clinical data in this area. Assessing use of rifabutin in this capacity is clinically important given its lower propensity for drug interactions compared to rifampin.
本病例系列描述了 7 例患者，他们在接受常规抗菌治疗的基础上，使用利福布丁替代利福平治疗与植入物相关的葡萄球菌感染。在开始使用利福布丁后的评估随访期内，有 2 例患者需要进行计划外的手术干预，定义为感染复发。2 例患者出现可能与治疗相关的不良反应。研究结果支持进一步研究利福布丁在不能使用利福平时作为葡萄球菌植入物感染辅助治疗的用途。本研究评估了利福布丁替代利福平用于辅助治疗葡萄球菌植入物相关感染的真实世界数据和临床结局。这是第二项研究该特定利福布丁用途的病例研究，表明该领域目前缺乏临床数据。鉴于利福布丁与药物相互作用的可能性低于利福平，评估其在这种情况下的使用具有重要的临床意义。
