Wentz A C, Jones G S, Rocco L, Matthews R R
Obstet Gynecol. 1975 Mar;45(3):256-62.
Luteinizing hormone releasing hormone (LHRH), 100 mug, was administered to 60 patients with secondary amenorrhea. No side effects or adverse reactions occurred. Delayed FSH and LH peak outputs were observed in patients receiving LHRH subcutaneously rather than intravenously, but responses were otherwise comparable. The majority of patients with secondary amenorrhea had responses which fell into the 95% confidence limits of responses for normal ovulating women. Responses of patients with different forms of dysfunction may be similar, and patients with similar pathology may respond quite differently. The LHRH stimulation test may assist in the diagnosis of particular hypothalamic, pituitary, or gonadal dysfunction, but it must be used clinically in the context of a carefully integrated study.
向60例继发性闭经患者注射了100微克促黄体生成激素释放激素（LHRH）。未出现副作用或不良反应。皮下注射而非静脉注射LHRH的患者观察到促卵泡生成素（FSH）和促黄体生成素（LH）峰值输出延迟，但其他方面的反应相当。大多数继发性闭经患者的反应落在正常排卵女性反应的95%置信区间内。不同功能障碍形式的患者反应可能相似，而病理情况相似的患者反应可能差异很大。LHRH刺激试验可能有助于诊断特定的下丘脑、垂体或性腺功能障碍，但必须在精心综合研究的背景下临床应用。
