Wentz A C, Jones G S, Barnes H V
Obstet Gynecol. 1975 Mar;45(3):247-55.
Thirty-eight patients with primary amenorrhea were evaluated by the administration of luteinizing hormone releasing hormone (LHRH). The LHRH stimulation test was not helpful in differentiating those patients who will proceed to normal menses from those who will continue to have prolonged dysfunction. Similar responses were observed in patients with different pathology, which indicates that the LHRH test must be utilized in conjunction with a carefully planned evaluation if it is to be useful in differentiating a hypothalamic from a pituitary defect. The finding of a patient with hypergonadotropism by serum radioimmunoassay and negative gonadotropins by bioassay suggests that the radioimmunoassay may detect a biologically inactive molecule and indicates that both assays are essential in the evaluation of primary amenorrhea.
通过给予促黄体生成素释放激素（LHRH）对38例原发性闭经患者进行了评估。LHRH刺激试验对于区分那些将恢复正常月经的患者和那些将继续存在长期功能障碍的患者并无帮助。在不同病理类型的患者中观察到了类似的反应，这表明如果要使LHRH试验有助于区分下丘脑缺陷和垂体缺陷，就必须结合精心规划的评估来使用。血清放射免疫测定显示高促性腺激素血症而生物测定显示促性腺激素阴性的一名患者的检查结果表明，放射免疫测定可能检测到一种无生物学活性的分子，并表明两种测定在原发性闭经的评估中都是必不可少的。
