Hoffmann-Sommergruber K
Department of Pathophysiology, University of Vienna, Austria.
Int Arch Allergy Immunol. 2000 Jul;122(3):155-66. doi: 10.1159/000024392.
In the recent past a great number of proteins causing type 1 allergic reactions in humans have been isolated and characterised. The main sources containing allergens are plants, mites, fungal spores and insects. Plant-derived allergens may either be taken in from the upper respiratory tract or they are present in a vast range of plant food causing food allergic reactions. Compared to the enormous amount of different plant proteins only a small number out of them are identified as a an allergen at present. Looking at the allergen encoding sequences, relationships by sequence similarity can be found quite frequently to a restricted number of plant protein families. Predominantly, these protein families are seed storage proteins, structural proteins and proteins involved in the defence-related system - pathogenesis-related proteins. In the following, a short overview of a number of pathogenesis-related protein families is presented in relation to the already known homologous plant allergens.
最近，大量可引发人类1型过敏反应的蛋白质已被分离和鉴定。含有过敏原的主要来源是植物、螨虫、真菌孢子和昆虫。植物衍生的过敏原既可以从呼吸道上部摄入，也存在于大量引发食物过敏反应的植物性食物中。与种类繁多的不同植物蛋白相比，目前只有少数被鉴定为过敏原。从过敏原编码序列来看，通过序列相似性发现，它们与数量有限的植物蛋白家族存在频繁的关联。主要来说，这些蛋白家族是种子储存蛋白、结构蛋白以及参与防御相关系统的蛋白——病程相关蛋白。以下是一些病程相关蛋白家族与已知同源植物过敏原相关的简要概述。
