Liefner M, Siebert H, Sachse T, Michel U, Kollias G, Brück W
Department of Neuropathology, Georg-August-Universität, Göttingen, Germany.
J Neuroimmunol. 2000 Aug 1;108(1-2):147-52. doi: 10.1016/s0165-5728(00)00262-9.
The role of TNF-alpha in the course of Wallerian degeneration of the sciatic nerve was studied in control and TNF-alpha deficient mice. In control animals, the characteristic phenomena of Wallerian degeneration such as axon and myelin degeneration as well as macrophage recruitment with subsequent myelin removal were observed. In TNF-alpha deficient mice, in contrast, macrophage recruitment into the degenerating nerves was impaired resulting in a delayed myelin removal. However, the myelin phagocytic capacity of macrophages was not affected as it could be demonstrated by a similar myelin load of control and TNF-alpha deficient macrophages. These data indicate that the main function of TNF-alpha during Wallerian degeneration is the induction of macrophage recruitment from the periphery without affecting myelin damage or phagocytosis.
在对照小鼠和肿瘤坏死因子-α（TNF-α）缺陷小鼠中研究了TNF-α在坐骨神经沃勒变性过程中的作用。在对照动物中，观察到了沃勒变性的特征性现象，如轴突和髓鞘变性以及巨噬细胞募集并随后清除髓鞘。相比之下，在TNF-α缺陷小鼠中，巨噬细胞向变性神经的募集受损，导致髓鞘清除延迟。然而，巨噬细胞的髓鞘吞噬能力未受影响，因为对照巨噬细胞和TNF-α缺陷巨噬细胞的髓鞘负载相似可以证明这一点。这些数据表明，TNF-α在沃勒变性过程中的主要功能是诱导外周巨噬细胞募集，而不影响髓鞘损伤或吞噬作用。
